Collagenase Type I

SKU: orb1741457

Description

Collagenase Type I is a proteolytic enzyme that selectively degrades collagen, making it a valuable research tool for studying connective tissue remodeling. Its applications include in vitro models of disc herniation and fibrosis, as well as in vivo research for conditions like Peyronie's disease and keloid scarring.

Research Area

Protein Biochemistry

Images & Validation

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Key Properties

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CAS Number	9001-12-1
Target	MMP
Solubility	H2O:50 mg/mL

Bioactivity

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In Vivo

METHODS: To investigate the effect of Collagenase Type II (similar to Collagenase Type I) on the cornea, the corneas of New Zealand white rabbits were treated with Collagenase Type II (200 μL at 5 mg/mL) for 30 minutes. RESULTS: Collagenase Type I increases the curvature and thinning of the cornea and reduces the elastic modulus, thereby simulating the pathological characteristics of Keratoconus (KC).

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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9001-12-1, Collagenase I, Collagenase Type I, Collagenase Type I (From microorganisms)

Quality Guarantee

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Quick Database Links

Gene Symbol

MMP

Protocol Information

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Purity:	>98% (HPLC)
CAS Number:	1178-24-1
MW:	432.43
Formula:	C₂₂H₂₄O₉

Purity:	>98% (HPLC)
CAS Number:	9001-12-1