CSRM617 hydrochloride

SKU: orb1709973

Description

CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2), binding its HOX domain with a Kd of 7.43 µM. It induces apoptosis via caspase-3 and PARP cleavage and has demonstrated good tolerability in mouse models of prostate cancer, supporting its use in oncology research.

Research Area

Cell Biology, Metabolism Research

Images & Validation

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Key Properties

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CAS Number	1353749-74-2
MW	291.69
Purity	99.59% (May vary between batches)
Formula	C₁₀H₁₄ClN₃O₅
SMILES	Cl.NC(CO)C(=O)N\N=C\c1ccc(O)c(O)c1O
Target	Androgen Receptor,Apoptosis
Solubility	DMSO:45 mg/mL (154.27 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (6.86 mM)

Bioactivity

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In Vivo

CSRM617, administered orally at a dosage of 50 mg/kg daily for 20 days, significantly inhibits tumor growth in SCID mice with 22Rv1 xenografts. This regimen was observed to notably impede the development and proliferation of diffuse metastases in the tested animal model.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Androgen Receptor, AndrogenReceptor, CSRM617 Hydrochloride, CSRM-617 Hydrochloride, CSRM617 hydrochloride(787504-88-5 Free base), CSRM 617 Hydrochloride

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Compound Identifiers

PubChem CID

136987959 ↗

Key Properties

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No computed properties available.

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