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CU-CPD107

SKU: orb1694658

Description

CU-CPD107 is a selective TLR8 agonist that exhibits context-dependent activity: it inhibits TLR8 signaling in the presence of R848 but acts as a co-agonist with ssRNA ligands. This small molecule is a valuable research tool for studying TLR8-mediated immune responses in both cellular and biochemical assay systems.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number2573912-32-8
MW400.25
Purity98.86%
FormulaC16H21IN2O2
SMILESC(C(C)(C)O)N1C(=C(I)N=C1COCC)C2=CC=CC=C2
TargetTLR
SolubilityDMSO:1.8 mg/mL (4.5 mM)

Bioactivity

Target IC50
TLR8 (HEK-Blue hTLR8 cells):13.7 μM
In Vitro
CU-CPD107 behaved an agonist in the presence of ssRNA in HEK-Blue hTLR8 cells, resulting in a fivefold activation at 100 μΜ by SEAP assay relative to the control. Crucially, CU-CPD107 displayed no agonistic potential in the absence of ssRNA.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

TLR8, CU CPD107, CU-CPD 107, CUCPD107, CU-CPD107, CU-CPD-107
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

CU-CPD107 (orb1694658)

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% DMSO +
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Available Sizes

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1 mg
¥ 1,300.00
5 mg
¥ 2,340.00
10 mg
¥ 3,380.00
25 mg
¥ 5,720.00
50 mg
¥ 7,930.00
100 mg
¥ 10,920.00
200 mg
¥ 14,560.00
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