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CWI1-2 HCL

SKU: orb1745214

Description

CWI1-2 HCL is a small molecule inhibitor of IGF2BP2 that disrupts its interaction with m6A-modified transcripts. This action promotes apoptosis and differentiation in leukemia cells, demonstrating therapeutic potential in preclinical research models.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number2408590-37-2
MW556.23
Purity99.18% (May vary between batches)
FormulaC22H18Cl4N6O3
SMILESOC1=CC=C(Cl)C=C1/C=N\N/C(N/N=C/C2=CC(Cl)=CC=C2O)=N/N=C/C3=CC(Cl)=CC=C3O.Cl
TargetApoptosis
Solubility10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (1.8 mM);DMSO:145 mg/mL (260.68 mM)

Bioactivity

In Vivo
CWI1-2 hydrochloride (5 mg/kg, i.v., once daily, 7-10 days) significantly delays leukemia onset and prolongs survival in BMT recipient B6.SJL (CD45.1) mice, without significantly affecting body weight.
In Vitro
CWI1-2 (0-1 μM, 24 h) hydrochloride demonstrates significant anti-leukemia efficacy.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Apoptosis, CWI1-2 HCL, CWI12HCL
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

CWI1-2 HCL (orb1745214)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,170.00
5 mg
¥ 1,950.00
1 ml x 10 mM (in DMSO)
¥ 2,340.00
10 mg
¥ 2,730.00
25 mg
¥ 4,810.00
50 mg
¥ 6,760.00
100 mg
¥ 9,360.00
200 mg
¥ 12,870.00
DispatchUsually dispatched within 3-5 working days
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