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CXCR2-IN-3

SKU: orb3174740

Description

CXCR2-IN-3 is a CXCR2 inhibitor with an IC50 of 11.37 μM. It inhibits the CXCR2-Ca2+ signaling pathway, thereby blocking autophagic flux and promoting ROS-mediated apoptosis. Additionally, CXCR2-IN-3 suppresses the CXCR2-NLRP3 canonical pathway, reducing the expression of tumor-promoting markers. This compound induces autophagy-dependent cell death in polyploid giant cancer cells (PGCC) and is applicable in studies related to oral squamous cell carcinoma (OSCC).

Images & Validation

Key Properties

TargetROS,NOD-like Receptor (NLR),Apoptosis,Autophagy,CXCR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information