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Cyclic-di-GMP disodium

SKU: orb1693269

Description

Cyclic-di-GMP disodium salt is a bacterial second messenger and STING pathway agonist. It is utilized in research on prokaryotic biofilm formation and, due to its antiproliferative effects and ability to induce cell cycle arrest, is investigated in oncology for potential cancer therapeutic development in both cellular and animal models.

Research Area

Immunology & Inflammation, Metabolism Research

Images & Validation

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Cyclic-di-GMP disodium

Key Properties

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CAS Number2222132-40-1
MW734.38
Purity98.98% (May vary between batches)
FormulaC20H22N10Na2O14P2
SMILESO=C1C2=C(NC(N)=N1)N([C@H]3[C@@H]([C@@]4([H])[C@](COP([O-])(O[C@]5([H])[C@@](O[C@@H](N6C7=C(C(N=C(N7)N)=O)N=C6)[C@@H]5O)([H])COP([O-])(O4)=O)=O)([H])O3)O)C=N2.[Na+].[Na+]
TargetEndogenous Metabolite,STING
SolubilityH2O:144 mg/mL (196.08 mM)

Bioactivity

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In Vivo
METHODS: Cyclic-di-GMP disodium (5GP-5GP disodium) (100 μg, intravenous injection) was used in mice in the primary and booster phases to verify whether it would further enhance the immune response to TriVax. RESULTS Cyclic-di-GMP disodium (5GP-5GP disodium) can effectively enhance the magnitude of the immune response produced by TriVax.
In Vitro
METHODS: H508 cells were treated with cyclized-di-GMP disodium (5GP-5GP disodium) (0.5-50 μM, 5 days) and cell proliferation was measured using a validated sulforhodamine B (SRB) colorimetric assay. RESULTS The highest concentration (50 μM) of c-di-GMP reduced H508 cell proliferation by approximately 15%. METHODS: Cyclic-di-GMP disodium (5GP-5GP disodium) (50, 100μM) was used to treat Jur kat cells, and the CD4 level in the cells was observed. RESULTS Cyclic-di-GMP disodium (5GP-5GP disodium) at a concentration of 50μM can induce a 6.3-fold increase in CD4 levels in Jur kat cells, and this was dose-dependent. Cyclic-di-GMP disodium (5GP-5GP disodium) at a concentration of 100μM treated Jur kat cells, resulting in a 9.1-fold increase in CD4 compared to the control group.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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CD4, c-di-GMP disodium, Cyclic di-GMP, Cyclic di-GMP (sodium salt), cyclic diguanylate disodium, Cyclic-di-GMP disodium, 3',5'-Cyclic diguanylic acid, 5GP-5GP disodium, EndogenousMetabolite, Endogenous Metabolite, STING
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Compound Identifiers

PubChem CID
137120247 ↗

Key Properties

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No computed properties available.

Protocol Information

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1 mg
$ 180.00
5 mg
$ 420.00
10 mg
$ 560.00
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