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CZL80

SKU: orb2566528

Description

CZL80 is a potent, brain-penetrant caspase-1 inhibitor (IC50 = 0.01 µM) used to study neuroinflammation. It reduces neuronal excitability, suppresses febrile seizures in vivo at 7.5 mg/kg i.v., and mitigates long-term deficits in stroke models, making it a key tool for seizure and stroke pathology research.

Research Area

Cell Biology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number313482-91-6
MW366.39
FormulaC19H14N2O4S
SMILESC(NC1=CC(C(O)=O)=CC=C1)(=O)C2=CC(NC(=O)C3=CC=CS3)=CC=C2
TargetCaspase
SolubilityDMSO:≥ 160 mg/mL

Bioactivity

Target IC50
Caspase-1:0.01 μM
In Vivo
CZL80 (10, 30 mg/kg/day, intraperitoneal injection, for 7 days) ameliorated motor dysfunction in C57BL/6 mice and Caspase-1⁻/⁻ mice after photothrombotic stroke . CZL80 (0.0075, 0.075, 0.75, and 7.5 mg/kg, intravenous injection, administered every other day) reduced epileptic seizure incidence in a dose-dependent manner, prolonged epileptic seizure latency, and increased the induction threshold of high-grade fever febrile convulsions in Casp1⁻/⁻ mice .

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CZL 80, CZL-80
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

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10 mg
$ 140.00
50 mg
$ 340.00
DispatchUsually dispatched within 5-10 working days
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