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Dabigatran etexilate

SKU: orb1310659

Description

Dabigatran etexilate is a direct thrombin inhibitor prodrug used in research to study anticoagulation. It is applied in vitro to assess thrombin activity and in vivo within animal models of thrombosis, aiding cardiovascular and hematological research.

Research Area

Pharmacology & Drug Discovery, Protein Biochemistry

Images & Validation

Key Properties

CAS Number211915-06-9
MW627.73
Purity98.19% (May vary between batches)
FormulaC34H41N7O5
SMILESCCCCCCOC(=O)N\N=C\c1ccc(NCc2nc3cc(ccc3n2C)C(=O)N(CCC(=O)OCC)c2ccccn2)cc1
TargetThrombin
SolubilityDMSO:116 mg/mL (184.79 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.37 mM);Ethanol:10 mg/mL (15.93 mM)

Bioactivity

Target IC50
DTI:4.5 nM (Ki)
In Vivo
Dabigatran has a concentration-dependent anticoagulant effect in various animals.Dabigatran reversibly inhibits human thrombin (Ki: 4.5 nM) and thrombin-induced platelet aggregation (IC50= 10 nM).
In Vitro
Dabigatran has a concentration-dependent anticoagulant effect in various animals.Dabigatran reversibly inhibits human thrombin (Ki: 4.5 nM) and thrombin-induced platelet aggregation (IC50= 10 nM).

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Dabigatran etexilate, Dabigatran, BIBR1048, BIBR-1048, BIBR 1048, anticoagulant, antithrombotic, atrial, active, agent, inhibit, orally, effects, fibrillation, Inhibitor, Thrombin, prodrug, venousthromboembolism

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

2 mg
$ 70.00
5 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 110.00
10 mg
$ 110.00
50 mg
$ 130.00
100 mg
$ 160.00
200 mg
$ 220.00
DispatchUsually dispatched within 3-5 working days
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