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Dabigatran

SKU: orb1300894

Description

Dabigatran

Research Area

Protein Biochemistry

Images & Validation

Key Properties

CAS Number211914-51-1
MW471.51
Purity97.44% (May vary between batches)
FormulaC25H25N7O3
SMILESCn1c(CNc2ccc(cc2)C(N)=N)nc2cc(ccc12)C(=O)N(CCC(O)=O)c1ccccn1
TargetThrombin
Solubility0.1 M HCL:12.5 mg/mL (26.51 mM);0.1M HCL:20.6 mg/mL (43.69 mM);DMSO:< 1 mg/mL (insoluble or slightly soluble);H2O:< 0.1 mg/mL (insoluble)

Bioactivity

Target IC50
Thrombin:9.3 nM
In Vivo
Dabigatran exhibits the most favorable activity profile following i.v. administration to rats. The bioavailability of dabigatran after p.o. administration of dabigatran etexilate is 7.2%. Dabigatran is predominantly excreted in the feces after p.o. treatment and in the urine after i.v. treatment. The mean terminal half-life of dabigatran is approximately 8 hours. Dabigatran acylglucuronides accounts for 0.4% and 4% of the dose in urine after p.o. and i.v. dosing, respectively.
In Vitro
Dabigatran is a very potent anticoagulant. Dabigatran shows that the terminal phenyl can be substituted by the more hydrophilic 2-pyridyl group without substantial loss of activity. Dabigatran inhibits thrombin, plasmin, factor Xa, trypsin, tPA and activated protein C with Ki of 4.5 nM, 1.7 μM, 3.8 μM, 50 nM, 45 μM and 20 μM, respectively. Dabigatran specifically and reversibly inhibits thrombin.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Dabigatran, BIBR 953, BIBR 953ZW, BIBR953, BIBR-953, inhibit, Inhibitor, Thrombin

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Key Properties

No computed properties available.

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Dabigatran (orb1300894)

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1 mg
¥ 1,040.00
2 mg
¥ 1,300.00
5 mg
¥ 1,690.00
10 mg
¥ 2,470.00
25 mg
¥ 4,290.00
50 mg
¥ 6,760.00
100 mg
¥ 9,620.00
500 mg
¥ 19,630.00
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