Danshensu sodium salt

SKU: orb1304816

Description

Sodium Danshensu, the sodium salt form of the key Danshen constituent danshensu, is a research compound for studying cardiovascular mechanisms. It has been shown in vitro to inhibit vasoconstriction induced by phenylephrine and CaCl₂ in calcium-free medium, supporting its investigation in vascular biology and hypertension research.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	67920-52-9
MW	220.16
Purity	99.94%
Formula	C₉H₉NaO₅
SMILES	[Na+].OC(Cc1ccc(O)c(O)c1)C([O-])=O
Target	Nrf2,Mitochondrial Metabolism,NF-κB,Apoptosis,Cytochromes P450,Autophagy
Solubility	10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (11.36 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:252.5 mg/mL (1146.89 mM);H2O:2 mg/mL (9.08 mM)

Bioactivity

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In Vivo

Danshensu is an effective free radical scavenger and antioxidant. Sodium danshensu exerts a biphasic action on vascular tension, where a low dose may induce minor contractions through a momentary increase in Ca2+ influx, while higher doses predominantly cause significant vasodilation by facilitating the opening of non-selective K+ channels and small-conductance Ca2+-sensitive K+ channels in vascular smooth muscle cells. Additionally, sodium danshensu inhibits vasoconstriction induced by norepinephrine and CaCl2 in a free Ca(2+) medium. Pre-treatment with sodium danshensu can suppress vasoconstriction triggered by norepinephrine and KCl in a dose-dependent manner.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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CYP450, Danshensu, Danshensu sodium, DanShenSu sodium sal, Danshensu sodium salt, Autophagy, (±)-DanShenSu sodium sal, (±)-DanShenSu sodium salt, inhibit, Inhibitor, Sodium Danshensu

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Compound Identifiers

PubChem CID

23711819 ↗

Key Properties

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No computed properties available.

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