Cart summary

You have no items in your shopping cart.

Darglitazone

SKU: orb1305841

Description

Darglitazone (CP-86325) is a potent and selective PPAR-γ agonist used in research for its antidiabetic properties. It has demonstrated efficacy in modulating glucose and lipid metabolism in both in vitro assays and in vivo animal models of type 2 diabetes and insulin resistance.

Research Area

Metabolism Research, Molecular Biology

Images & Validation

Key Properties

CAS Number141200-24-0
MW420.48
Purity99.76%
FormulaC23H20N2O4S
SMILESC(CC(=O)C1=CC=C(CC2SC(=O)NC2=O)C=C1)C=3N=C(OC3C)C4=CC=CC=C4
TargetPPAR
Solubility10% DMSO+90% Corn Oil:2.5 mg/mL (5.95 mM);Ethanol:≤ 5 mg/mL;DMSO:55 mg/mL (130.8 mM)

Bioactivity

In Vivo
In male diabetic ob/ob mice, Darglitazone dramatically reduces the infarct size in the ob/ob mice at 24 h of recovery. Normalized blood glucose and reduced circulating triglycerides (TG) and very-low-density lipoproteins (VLDL) in diabetic ob/ob mice without having any effect in the nondiabetic mice. Darglitazone treatment restores acute cerebral inflammatory responses that were absent in the diabetic mice and profoundly improved their recovery from hypoxic-ischemic (H/I) insult.
In Vitro
Darglitazone (30 μM) stimulated UCP2 gene expression, likely through PPAR-γ, and increased UCP2 mRNA levels in cell lines representing white (3T3-L1 and 3T3-F442A), brown (HIB-1B) adipose tissues, and skeletal muscle (L6) .

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, oral, inhibit, Diabetes, CP 86325, CP86325, CP-86325, Darglitazone, corticosterone, UCP2, thiazolidinedione, PPAR, PPARγ, PPAR-γ, Peroxisome proliferator-activated receptors

Similar Products

  • Darglitazone Sodium [orb1687468]

    149904-87-0

    444.48

    C23H21N2NaO4S

    50 mg, 100 mg, 25 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

Darglitazone (orb1305841)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
¥ 1,040.00
5 mg
¥ 1,300.00
10 mg
¥ 1,690.00
25 mg
¥ 2,470.00
50 mg
¥ 3,510.00
100 mg
¥ 4,810.00
200 mg
¥ 6,630.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry