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Darglitazone

SKU: orb1305841

Description

Darglitazone (CP-86325) is a potent and selective PPAR-γ agonist used in research for its antidiabetic properties. It has demonstrated efficacy in modulating glucose and lipid metabolism in both in vitro assays and in vivo animal models of type 2 diabetes and insulin resistance.

Research Area

Metabolism Research, Molecular Biology

Images & Validation

Key Properties

CAS Number141200-24-0
MW420.48
Purity99.19% (May vary between batches)
FormulaC23H20N2O4S
SMILESC(CC(=O)C1=CC=C(CC2SC(=O)NC2=O)C=C1)C=3N=C(OC3C)C4=CC=CC=C4
TargetPPAR
Solubility10% DMSO+90% Corn Oil:2.5 mg/mL (5.95 mM);Ethanol:≤ 5 mg/mL;DMSO:55 mg/mL (130.8 mM)

Bioactivity

In Vivo
In male diabetic ob/ob mice, Darglitazone dramatically reduces the infarct size in the ob/ob mice at 24 h of recovery. Normalized blood glucose and reduced circulating triglycerides (TG) and very-low-density lipoproteins (VLDL) in diabetic ob/ob mice without having any effect in the nondiabetic mice. Darglitazone treatment restores acute cerebral inflammatory responses that were absent in the diabetic mice and profoundly improved their recovery from hypoxic-ischemic (H/I) insult.
In Vitro
Darglitazone (30 μM) stimulated UCP2 gene expression, likely through PPAR-γ, and increased UCP2 mRNA levels in cell lines representing white (3T3-L1 and 3T3-F442A), brown (HIB-1B) adipose tissues, and skeletal muscle (L6) .

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, oral, inhibit, Diabetes, CP 86325, CP86325, CP-86325, Darglitazone, corticosterone, UCP2, thiazolidinedione, PPAR, PPARγ, PPAR-γ, Peroxisome proliferator-activated receptors

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Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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2 mg
$ 80.00
5 mg
$ 100.00
10 mg
$ 130.00
25 mg
$ 190.00
50 mg
$ 270.00
100 mg
$ 370.00
200 mg
$ 510.00
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