Datopotamab deruxtecan Antibody

SKU: orb1984608

Description

Datopotamab deruxtecan is a TROP2-directed antibody-drug conjugate (ADC) demonstrating potent antitumor activity. It exhibits antibody-dependent cellular cytotoxicity in vitro and effectively suppresses tumor growth in xenograft models, supporting its research in oncology for both in vitro and in vivo experimental applications.

Research Area

Immunology & Inflammation, Molecular Biology

Images & Validation

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Key Properties

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CAS Number	2238831-60-0
MW	145.16 kDa
Purity	98.46% (SEC-HPLC)
Target	Topoisomerase,TROP2,Antibody-Drug Conjugates (ADCs)

Bioactivity

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Target IC50	BxPC-3 cells (Trop2-expressing):74.6 ng/mL\|HGSOC cells (TROP2-negative) viability:5.1 µM\|TROP2-over expressing HGSOC cells viability:0.49 µM\|CFPAC-1 cells (Trop2-expressing):706 ng/mL Read more...
In Vivo	Datopotamab deruxtecan exhibited significant antitumor activity in a variety of TROP2-expressing xenograft tumors, and 6 mg/kg Datopotamab deruxtecan treatment of a patient-derived xenograft (PDX) model of non-small-cell lung cancer (NSCLC) induced tumor regression. In addition, Datopotamab deruxtecan has an acceptable safety profile in rats and crab-eating monkeys. Read more...
In Vitro	Datopotamab deruxtecan specifically binds to TROP2. 100 μg/mL Datopotamab deruxtecan is internalized into the tumor cell and reaches the lysosome via the intracellular transport pathway and releases Deruxtecan. In vitro experiments Datopotamab deruxtecan caused DNA damage and triggered apoptosis in tumor cells expressing TROP2. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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AntibodyDrug Conjugates (ADCs), Antibody-Drug Conjugates (ADCs), Antibody-Drug Conjugates, AntibodyDrugConjugates(ADCs), AntibodyDrugConjugates, ADCs, Dato-DXd, Datopotamab deruxtecan, DS1062, DS-1062, DS 1062, S-1062a, Topoisomerase

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Gene Symbol

Topoisomerase,TROP2,Antibody-Drug Conjugates (ADCs)

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