Dazostinag disodium

SKU: orb1744875

Description

Dazostinag disodium (TAK-676) is a synthetic STING agonist that activates the STING pathway and induces type I interferon production. It functions as a potent immune modulator, promoting durable anti-tumor T cell immunity and interferon-dependent responses, which have been investigated in preclinical cancer immunotherapy studies.

Research Area

Immunology & Inflammation

Images & Validation

−

Key Properties

−

CAS Number	2553413-93-5
MW	754.48
Purity	99.96%
Formula	C₂₁H₂₀F₂N₈Na₂O₁₀P₂S₂
SMILES	O[C@H]1[C@@]2([C@@H](O[C@@]1(COP([S-])(O[C@@]3([C@@]([H])(COP([S-])(O2)=O)O[C@H]([C@@H]3F)N4C5=NC=NC(N)=C5N=C4)[H])=O)[H])N6C7=C(C(F)=C6)C(N=CN7)=O)[H].[Na+].[Na+]
Target	STING
Solubility	DMSO:250 mg/mL (331.35 mM)

Bioactivity

−

Target IC50	CD8+:0.216 μM\|natural killer cell:0.271 μM\|CD4+:0.249 μM
In Vivo	METHODS: Mice were injected subcutaneously into the right flank with CT26, WT tumor cells, A20 tumor cells, or B16F10 tumor cells, and Dazostinag disodium (TAK-676) (0.3, 1.0, 2.0 mg/kg, intravenously, once every three days, 3 times), and the effects on tumor growth were evaluated by measuring growth rate inhibition (GRI) and tumor regression. RESULTS When Dazostinag disodium (TAK-676) was administered at a dose of 1 mg/kg, BALB/c mice bearing A20 syngeneic tumors showed significant antitumor activity compared to vehicle treatment (GRI 72%, P < 0.001); similar to the A20 tumor model, CT26 tumor-bearing animals treated with 1 mg/kg of Dazostinag disodium (TAK-676) also showed tumor control over vehicle-treated animals; when the dose of Dazostinag disodium (TAK-676) was increased from 1.0 to 2.0 mg/kg, the antitumor activity was significantly increased in both the A20 (GRI=91%, P < 0.001) and CT26 (GRI=132%, P < 0.001) models. Read more...
In Vitro	METHODS: The ability of TAK-676 to activate the STING pathway was evaluated in human THP1-Dual and mouse CT26 cells treated with dazostinag disodium (TAK-676) (1.1, 3.3, 10 μM, 2 hours). RESULTS Expression of pSTING (S366), pTBK1 (S172), and pIRF3 (S396) was dose-dependently induced in both mouse and human cell lines. Read more...

Storage & Handling

−

Storage	store at low temperature,keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

TAK676, TAK-676, TAK 676, STING, Dazostinag, Dazostinag disodium

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID

165412584 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols