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dBET6

SKU: orb1225790

Description

dBET6 is a highly cell-permeable, optimized chemical degrader of BET bromodomain BED4, does not directly affect CDK9 localization.

Images & Validation

Key Properties

CAS Number1950634-92-0
MW841.381
Purity>98% (HPLC)
FormulaC42H45ClN8O7S
SMILESO=C(NCCCCCCCCNC(COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)=O)C[C@H]4C5=NN=C(C)N5C6=C(C(C)=C(C)S6)C(C7=CC=C(Cl)C=C7)=N4
TargetPROTAC
SolubilityDMSO: 10 mM ( < 1 mg/ml refers to the product slightly soluble or insoluble )

Bioactivity

In Vivo
dBET6 (7.5 mg/kg, p.o. , BID) reduces the leukemic burden in a disseminated mouse model of T-ALL.
In Vitro
dBET6 is a highly potent, selective and cell-permeable degrader of BET with an IC50 of 14 nM. dBET6 (100 nM) exhibits antitumor activity against T cell acute lymphoblastic leukemia (T-ALL) lines via degradation of BRD4.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

dBET 6

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  • dBET6 [orb1302063]

    97.57% (May vary between batches)

    1950634-92-0

    841.37

    C42H45ClN8O7S

    1 mg, 5 mg, 10 mg, 50 mg, 100 mg, 500 mg, 200 mg, 25 mg, 1 ml x 10 mM (in DMSO)
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Protocol Information

dBET6 (orb1225790)

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Available Sizes

Select a size below

5 mg
¥ 2,080.00
10 mg
¥ 3,250.00
25 mg
¥ 5,720.00
50 mg
¥ 8,970.00
100 mg
¥ 12,870.00
500 mg
¥ 23,270.00