DCH36_06

SKU: orb1298142

Description

DCH36_06 is a potent and selective small molecule inhibitor of the p300/CBP histone acetyltransferase. This compound is used in research to probe epigenetic mechanisms in vitro and has shown activity in cellular models of oncology and other diseases dependent on transcriptional coactivators.

Research Area

Cell Biology, Epigenetics & Chromatin

Images & Validation

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Key Properties

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CAS Number	593273-05-3
MW	372.83
Purity	98.32% (May vary between batches)
Formula	C₁₈H₁₃ClN₂O₃S
SMILES	Cc1ccc(cc1Cl)N1C(=S)NC(=O)\C(=C/C=C/c2ccco2)C1=O
Target	Histone Acetyltransferase,Apoptosis,Epigenetic Reader Domain
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.73 mM);DMSO:120 mg/mL (321.86 mM)

Bioactivity

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Target IC50	CBP:3.2 μM\|p300:0.6 μM
In Vivo	DCH36_06 blocked the leukemic xenograft growth in mice supporting its potential for in vivo use that underlies the therapeutic potential for p300/CBP inhibitors in clinical translation. Read more...
In Vitro	DCH36_06 mediated p300/CBP inhibition leading to hypoacetylation on H3K18 in leukemic cells. The suppression of p300/CBP activity retarded cell proliferation in several leukemic cell lines.In addition, DCH36_06 arrested cell cycle at G1 phase and induced apoptosis via activation of capase3, caspase9 and PARP that elucidated the molecular mechanism of its anti-proliferation activity. In transcriptome analysis, DCH36_06 altered downstream gene expression and apoptotic pathways-related genes verified by real-time PCR. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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p300, EpigeneticReaderDomain, Epigenetic Reader Domain, HATs, HAT, Inhibitor, hypoacetylation, Histone Acetyltransferase, HistoneAcetyltransferase, inhibit, (5E)-1-(3-chloro-4-methylphenyl)-5-[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione, Apoptosis, antiproliferative, anti-tumor, DCH36_06, DCH-36_06, CBP

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Compound Identifiers

PubChem CID

1797299 ↗

Key Properties

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No computed properties available.

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DCH36_06 (orb1298142)

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DCH36_06

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Quality Guarantee

Compound Identifiers

Key Properties

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Protocol Information

DCH36_06 (orb1298142)

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