Dersimelagon

SKU: orb1702360

Description

Dersimelagon (MT-7117) is an orally bioavailable, selective MC1R agonist with high affinity for human, monkey, mouse, and rat receptors. It is utilized in research to investigate skin pigmentation mechanisms, including in vitro receptor activation studies and in vivo models of dermatological conditions.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	1835256-48-8
MW	675.75
Purity	97.35% (May vary between batches)
Formula	C₃₆H₄₅F₄N₃O₅
SMILES	C(=O)([C@@]1(F)[C@@H](CN(C1)C2CCCC2)C3=CC=C(OC)C=C3)N4C[C@@H]([C@@H](COC)C4)C5=C(C=C(C(F)(F)F)C=C5)N6CCC(C(O)=O)CC6
Target	Melanocortin Receptor
Solubility	DMSO:6.76 mg/mL (10 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.48 mM)

Bioactivity

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Target IC50	MC4R (human):32.9 nM (Ki)\|MC4R (human):79.6 nM (EC50)\|MC1R (rat):0.251 nM (EC50)\|MC2R (human):>10000 nM (EC50)\|MC1R (human):2.26 nM (Ki)\|MC1R (human):8.16 nM (EC50)\|MC3R (human):1420 nM (Ki)\|MC5R (human):486 nM (Ki)\|MC1R (mouse):1.14 nM (EC50)\|MC1R (cynomolgus monkey):3.91 nM (EC50)
In Vivo	METHODS: Dersimelagon (MT-7117) (0.003, 0.03, 0.3, 3 mg/kg; oral administration for 6 days) was used to observe the effect of Dersimelagon (MT-7117) on the hair of Ay/a mice. RESULTS MT-7117 induced the synthesis of eumelanin, but not pheomelanin, in the hair roots of Ay/a mice.
In Vitro	METHODS: B16F1 cells were treated with Dersimelagon (MT-7117) (0, 0.03, 0.1, 0.3, 1, 3, 10, 30, 100, 300 pM; 3 days) to evaluate the ability of Dersimelagon (MT-7117) to induce eumelanin production. RESULTS Dersimelagon (MT-7117) increased eumelanin production in a concentration-dependent manner with an EC50 of 13 pM in B16F1 cells.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Dersimelagon, MT7117, MT-7117, MT 7117, MelanocortinReceptor, melanocortin-1 receptor, Melanocortin Receptor

Quality Guarantee

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Compound Identifiers

PubChem CID

126736894 ↗

Key Properties

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No computed properties available.

Protocol Information

Find More Protocols

CAS Number:	2490660-87-0
MW:	773.75
Formula:	C₃₆H₄₈F₄N₃O₉P

Dersimelagon

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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