Desglymidodrine

SKU: orb2279203

Description

Desglymidodrine (ST 1059) is the active metabolite of Midodrine and functions as a selective α1-adrenoceptor agonist. This vasoconstrictor is utilized in cardiovascular research, including studies on neurocardiogenic syncope, and is applicable in both in vitro receptor assays and in vivo hemodynamic models.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	3600-87-1
MW	197.23
Purity	99.56%
Formula	C₁₀H₁₅NO₃
SMILES	OC(C1=CC(OC)=CC=C1OC)CN
Target	Adrenergic Receptor,Drug Metabolite
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (10.14 mM);DMSO:40 mg/mL (202.81 mM)

Bioactivity

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Target IC50

α1D-adrenoceptor (rat):5.78 (pKi)|α2A-adrenoceptor (human):5.83 (pKi)|α1B-adrenoceptor (rat):5.16 (pKi)|α1A-adrenoceptor (rat):5.89 (pKi)

In Vitro

Desglymidodrine affects venoconstriction over a concentration range of 1-1000 μM, with a pD2 value of 4.64 (-log mol/L) in isolated canine femoral veins and 4.48 (-log mol/L) in isolated human saphenous veins. Desglymidodrine binds to α1A, α1B, and α1D adrenergic receptors in rats and α2A adrenergic receptors in humans, corresponding to pKi values of 5.89, 5.16, 5.78, and 5.83, respectively.

Storage & Handling

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Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Desglymidodrine, ST1059, ST 1059

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Compound Identifiers

PubChem CID

43260 ↗

Key Properties

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No computed properties available.

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