Dexmedetomidine hydrochloride

SKU: orb1300744

Description

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	145108-58-3
MW	236.74
Purity	99.94%
Formula	C₁₃H₁₆N₂·HCl
SMILES	Cl.C[C@H](c1cnc[nH]1)c1cccc(C)c1C
Target	Adrenergic Receptor
Solubility	H2O:23.7 mg/mL (100.11 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.45 mM);DMSO:55 mg/mL (232.32 mM)

Bioactivity

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Target IC50	α2-adrenoceptor:1.08 nM (IC50)
In Vivo	METHODS: Using C57BL/6J mice exposed to LPS, we investigated whether Dexmedetomidine hydrochloride (Precedex) (50 μg/kg, intraperitoneal injection) provides lung protection by regulating mitochondrial dynamics via the HIF-1a/HO-1 pathway in vivo. RESULTS Dexmedetomidine hydrochloride (Precedex) alleviated lung pathological damage, reduced the oxidative stress index (OSI), improved mitochondrial dysfunction, upregulated the expression of HIF-1α and HO-1, and was accompanied by a shift in mitochondrial dynamics to fusion. Read more...
In Vitro	METHODS: NR8383 alveolar macrophages were stimulated with 10 μg/ml LPS for 24 hours and then treated with Dexmedetomidine hydrochloride (Precedex) (0.01, 0.1, 1, 10, 50 μM, 2 hours) for another 2 hours. CCK-8 assay was used to evaluate the effect of different concentrations of Dexmedetomidine hydrochloride (Precedex) pretreatment on the viability of LPS-treated NR8383 cells. RESULTS Cell viability gradually increased with increasing concentrations of Dexmedetomidine hydrochloride (Precedex). Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Medetomidine Hydrochloride, inhibit, Inhibitor, anxiolysis, analgesia, Adrenergic Receptor, AdrenergicReceptor, adrenoceptor, (S)-Medetomidine, (S)-Medetomidine hydrochloride, (+)-Medetomidine, (+)-Medetomidine hydrochloride, Dexmedetomidine, Dexmedetomidine HCl, Dexmedetomidine hydrochloride, Dexmedetomidine Hydrochloride, Beta Receptor, sedation, Precedex, α2-adrenoceptor

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Compound Identifiers

PubChem CID

6918081 ↗

Key Properties

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No computed properties available.

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