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DG-041

SKU: orb1308390

Description

DG-041

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number861238-35-9
MW592.32
Purity99.77%
FormulaC23H15Cl4FN2O3S2
SMILESCc1cn(Cc2ccc(Cl)cc2Cl)c2c(\C=C\C(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)cc(F)cc12
TargetProstaglandin Receptor
SolubilityDMSO:55 mg/mL (92.86 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.38 mM)

Bioactivity

Target IC50
EP3 receptor:4.6/8.1 nM
In Vivo
DG-041 has CL of 1250 mL/h/kg for intravenous. DG-041 (1.78 mg/kg for i.v or 9.62 mg/kg for p.o) has t1/2 of 2.7 hours, 4.06 hours. DG-041 (1.78 mg/kg for i.v or 9.62 mg/kg for p.o) has Cmax of 9.46 μM, 2.74 μM for intravenous and oral administration, respectively .
In Vitro
DG-041 was a less effective the DP1 (IC50: 131 nM), EP1 (IC50: 486 nM) and TP receptors (IC50: 742 nM) antagonist .

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

blood-brain, barrier, atherothrombosis, atherosclerotic, DG041, DG-041, DG 041, infarction, Myocardial, inhibit, EP3 receptor, EP3, Inhibitor, stroke, plaque, Prostaglandin Receptor, ProstaglandinReceptor
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Key Properties

No computed properties available.

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Protocol Information

DG-041 (orb1308390)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,170.00
2 mg
¥ 1,430.00
5 mg
¥ 1,820.00
1 ml x 10 mM (in DMSO)
¥ 2,080.00
10 mg
¥ 2,730.00
25 mg
¥ 4,680.00
50 mg
¥ 7,930.00
100 mg
¥ 11,180.00
500 mg
¥ 22,490.00
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