diABZI STING agonist-1 (Tautomerism)

SKU: orb1709872

Description

diABZI STING agonist-1 is a potent and selective small molecule agonist of the STING receptor, exhibiting EC50 values of 130 nM for human and 186 nM for mouse STING. It is widely used in immuno-oncology and antiviral research to stimulate innate immune responses in both cellular assays and animal studies.

Research Area

Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	2138498-18-5
MW	849.94
Purity	99.72% (May vary between batches)
Formula	C₄₂H₅₁N₁₃O₇
SMILES	C(/C=C/CN1C=2C(N=C1NC(=O)C=3N(CC)N=C(C)C3)=CC(C(N)=O)=CC2OC)N4C=5C(N=C4NC(=O)C=6N(CC)N=C(C)C6)=CC(C(N)=O)=CC5OCCCN7CCOCC7
Target	STING
Solubility	DMSO:100 mg/mL (117.66 mM)

Bioactivity

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Target IC50	H69AR cells:0.035 μM (EC50)\|STNG (mouse):186 nM (EC50)\|STNG (human, PBMC cells):130 nM (EC50)\|H69AR cells:0.055 μM (EC50)
In Vivo	diABZI STING agonist-1 (Tautomerism)(subcutaneous injection; 2.5 mg/kg) induces STING-dependent activation of type I interferon and proinflammatory cytokines in vivo. diABZI STING agonist-1 (Tautomerism) (intravenous; 3 mg/kg) exhibited systemic exposure with a half-life of 1.4 hours and reached a systemic concentration greater than half the maximum effective concentration of STING in mice (EC50) 200 ng/kg) ml). diABZI STING agonist-1 (Tautomerism) (intravenous; 1.5 mg / kg; 43 days) can significantly inhibit tumor growth and significantly improve survival rate (P <0.001). Eight out of 10 mice are tumor-free. Read more...
In Vitro	diABZI STING agonist-1 (Tautomerism) is a selective stimulator of interferon gene (STING) receptor agonists, with EC50 of 130 and 186 nM for humans and mice, respectively. diABZI STING agonist-1 (Tautomerism) at a concentration of 1 μM showed high selectivity for more than 350 kinases tested. Read more...

Storage & Handling

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Storage	store at low temperature,keep away from direct sunlight,The compound is unstable in solution. Please use soon \| Powder: -20°C for 3 years \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Compound 3, diABZI STING agonist, diABZI STING agonist (Compound 3), diABZI STING agonist-1, Tautomerism, STING

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Compound Identifiers

PubChem CID

131986624 ↗

Key Properties

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No computed properties available.

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