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Diclofensine

SKU: orb1685506

Description

Diclofensine (Ro 8-4650) and dAURK-4 hydrochloride are potent triple monoamine reuptake inhibitors, effectively blocking dopamine, norepinephrine, and serotonin transporters. These compounds are valuable research tools for studying neurotransmitter systems in neuropharmacology, with applications in both in vitro binding assays and in vivo behavioral models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number67165-56-4
MW322.23
Purity97.01% (May vary between batches)
FormulaC17H17Cl2NO
SMILESCOc1ccc2C(CN(C)Cc2c1)c1ccc(Cl)c(Cl)c1
TargetDopamine Receptor,5-HT Receptor,Monoamine Transporter

Bioactivity

In Vivo
A controlled trial with diclofensine, a new psychoactive drug, in the treatment of depression.
Animal Research
In a controlled study, out-patients suffering from moderate to severe depression were treated with the objective of assessing the new drug's therapeutically effective dose range. Maprotiline was used as a reference drug: fourteen patients were assigned to receive diclofensine and thirteen to receive maprotiline in a double-blind design. Depending on tolerance and efficacy, they were treated for periods ranging from 5 to 150 days. Doses were titrated to the optimum.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

DAT, Diclofensine, DopamineReceptor, Dopamine Transporter, Dopamine, Dopamine Receptor, 5HTReceptor, 5-HT, 5HT Receptor, MonoamineTransporter, Monoamine transporter, Monoamine Transporter, Neuroscience, SLC6A3, Ro 8-4650

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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5 mg
$ 90.00
10 mg
$ 130.00
25 mg
$ 190.00
50 mg
$ 270.00
100 mg
$ 380.00
DispatchUsually dispatched within 4-6 weeks
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