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Dihydrorotenone

SKU: orb1297393

Description

Dihydrorotenone is a potent inhibitor of mitochondrial complex I. It is widely used in research to model Parkinsonian syndrome in vitro and in vivo, facilitating studies in neurotoxicity and neurodegenerative disease mechanisms.

Research Area

Cell Biology, Metabolism Research, Signal Transduction

Images & Validation

Key Properties

CAS Number6659-45-6
MW396.43
Purity99.58% (May vary between batches)
FormulaC23H24O6
SMILES[H][C@@]12COc3cc(OC)c(OC)cc3[C@]1([H])C(=O)c1ccc3O[C@H](Cc3c1O2)C(C)C
TargetApoptosis|||Mitochondrial Metabolism
SolubilityDMSO:27.5 mg/mL (69.37 mM);10% DMSO+90% Corn Oil:2 mg/mL (5.05 mM)

Bioactivity

In Vitro
Dihydrorotenone arrested human plasma cancer cells at the G0/G1 phase of the cell cycle. Dihydrorotenone inhibited cyclin D2 transactivation, thus inhibiting its mRNA expression. In addition, Dihydrorotenone upregulated the cell cycle repressors p21 and p53. Dihydrorotenone also increased the phosphorylation level of p53, suggesting the upregulated transactivation function of p53, which was confirmed by the induction of p21, a substrate of activated p53. Moreover, Dihydrorotenone downregulated AKT and ERK phosphorylation, an incentive of cell cycle progression.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

p53, MitochondrialMetabolism, Mitochondrial Metabolism, inhibit, Inhibitor, ERK, Dihydrorotenone, Apoptosis, Akt

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 mg
$ 160.00
5 mg
$ 320.00
1 ml x 10 mM (in DMSO)
$ 380.00
10 mg
$ 490.00
25 mg
$ 780.00
50 mg
$ 1,030.00
DispatchUsually dispatched within 5-10 working days
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