Dimaprit dihydrochloride

SKU: orb1218357

Description

Dimaprit dihydrochloride is a selective histamine H2 receptor agonist. Dimaprit dihydrochloride also inhibits nNOS with an IC50 of 49 μM. It can stimulate gastric acid secretion.

Images & Validation

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Key Properties

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CAS Number	23256-33-9
MW	234.19
Purity	>98% (HPLC)
Formula	C₆H₁₅N₃S·2HCl
SMILES	NC(SCCCN(C)C)=N.[H]Cl.[H]Cl
Target	Histamine Receptor
Solubility	H2O:<23.42mg/ml

Bioactivity

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In Vivo

Dimaprit stimulates gastric acid secretion in rats (1.25 μM/kg/min; rapid i. v. injection), cats (2-64 μM/h; i. v.) and dogs (1-100 nM/kg/min; i. v.). Dimaprit (0.01-1 μM/kg; i. v. at intervals of 5 min) causes dose-dependent falls in blood pressure in cats. Dimaprit (1-100 nM; intra-arterial injection) causes vasodilatation in the femoral vascular bed, and it (1 μM/kg; bolus or intravenous injection) has no effect on heart rate.

In Vitro

Dimaprit has less than 0.0001% the activity of histamine on H1-receptors. Dimaprit (0.1 nM-100 μM) inhibits nNOS concentration dependently with an IC50 of 49±14 μM.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Quick Database Links

Gene Symbol

Histamine Receptor

Protocol Information

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