Dimethyl fumarate

SKU: orb1310560

Description

Dimethyl fumarate (DMF) is an orally active, blood-brain barrier permeable Nrf2 activator. It exhibits antimicrobial, anti-inflammatory, and immunomodulatory properties, making it a valuable research tool for studying multiple sclerosis and neuroinflammatory diseases in both in vitro and in vivo models.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	624-49-7
MW	144.13
Purity	90.51% (May vary between batches)
Formula	C₆H₈O₄
SMILES	COC(=O)\C=C\C(=O)OC
Target	Endogenous Metabolite\|\|\|Reactive Oxygen Species\|\|\|Autophagy\|\|\|Nrf2\|\|\|HIV Protease
Solubility	10% DMSO+90% Saline:1.5 mg/mL (10.41 mM);DMSO:40 mg/mL (277.53 mM);Ethanol:7.2 mg/mL (49.95 mM);5% DMSO+95% Saline:0.29 mg/mL (2.01 mM)

Bioactivity

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In Vivo

METHODS: To study the effects on Friedreich's ataxia (FA), Dimethyl fumarate (110 mg/kg) was administered orally to a FXNKD mouse model of FA once daily for 18 weeks. RESULTS: Dimethyl fumarate rescued these enzyme activities in the brain of the FXNKD mouse model and rescued frataxin and cytochrome oxidase expression in the brain, cerebellum, and quadriceps muscle.

In Vitro

METHODS: Primary cortical cultures or hippocampal HT22 cells were treated with Dimethyl fumarate (10 µM) and glutamate for 24 h. Cell viability was measured by Cell Titer Blue (CTB) assay. RESULTS: Pre-incubation with 10 µM MMF Dimethyl fumarate for 24 h protected primary cortex cultures and hippocampal HT22 cells from oxidized glutamate toxicity. METHODS: Tumor cells CT26 were treated with Dimethyl fumarate (100 µM) for 3-24 h. LDH release was detected by LDH cytotoxicity assay kit. RESULTS: Dimethyl fumarate time-dependently increased LDH release, which reflected necrotic cell death.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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EndogenousMetabolite, Endogenous Metabolite, Inhibitor, Human immunodeficiency virus, HIVProtease, HIV Protease, HIV, neuroprotective, KEAP1-Nrf2, Keap1-Nrf2, inhibit, Autophagy, Antioxidant, anti-inflammatory, brain-penetrant, DMF, Dimethyl, Dimethyl fumarate, Dimethyl Fumarate, ROS, sclerosis, ReactiveOxygenSpecies, Reactive Oxygen Species

Quality Guarantee

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Compound Identifiers

PubChem CID

637568 ↗

Key Properties

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No computed properties available.

Protocol Information

Find More Protocols

CAS Number:	1588866-45-8
MW:	412.39
Formula:	C₂₂H₂₀O₈

CAS Number:	66487-95-4
MW:	150.16
Formula:	C₆H₈O₄

CAS Number:	1616345-41-5
MW:	133.12
Formula:	C₅H₆O₄

CAS Number:	23057-98-9
MW:	146.14
Formula:	C₆D₂H₆O₄

Purity:	≥98% (May vary between batches)
CAS Number:	2756-87-8
MW:	130.1
Formula:	C₅H₆O₄

Dimethyl fumarate

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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