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β,β-Dimethylacrylshikonin

SKU: orb1303348

Description

Dimethylacrylshikonin is a bioactive small molecule that demonstrates anti-tumor activity both in vitro and in vivo. It induces apoptosis in cancer cells like MCF-7 and SGC-791 by modulating Bcl-2/Bax, ERK, and NF-κB pathways, and enhances radiotherapy efficacy in HCT-116 xenograft models.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Neuroscience, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number24502-79-2
MW370.396
Purity99.97% (May vary between batches)
FormulaC21H22O6
SMILESC\C(C)=C/C[C@@H](OC(=O)\C=C(\C)C)C1=CC(=O)c2c(O)ccc(O)c2C1=O
TargetHIF/HIF Prolyl-Hydroxylase,ERK,Gamma-secretase,Bcl-2 Family,Apoptosis,NO Synthase
SolubilityDMSO:8.55 mg/mL (23.08 mM)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

beta, beta-Dimethylacrylshikonin, beta,beta-Dimethylacrylshikonin, Dimethylacrylshikonin, b, b-Dimethylacrylshikonin, b,b-Dimethylacrylshikonin, inhibit, Isoarnebin I, HIFProlylHydroxylase, HIF/HIFProlylHydroxylase, HIF/HIF ProlylHydroxylase, HIF-1α, HIF Prolyl-Hydroxylase, HIF ProlylHydroxylase, HIF, Inhibitor, ERK, β, β-Dimethylacrylshikonin, β,β Dimethylacrylshikonin, β,βDimethylacrylshikonin, β,β-Dimethylacrylshikonin

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

2 mg
$ 70.00
5 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 90.00
10 mg
$ 120.00
25 mg
$ 190.00
50 mg
$ 260.00
100 mg
$ 360.00
200 mg
$ 540.00
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