Disufenton sodium

SKU: orb1300986

Description

Disufenton sodium (NXY-059) is a nitrone-based free radical trapping agent with demonstrated neuroprotective properties. It has been investigated in preclinical models of acute ischemic stroke, showing efficacy in reducing infarct volume in both in vitro and in vivo studies.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	168021-79-2
MW	381.33
Purity	98.66%
Formula	C₁₁H₁₃NNa₂O₇S₂
SMILES	[Na+].[Na+].CC(C)(C)[N+](\[O-])=C\c1ccc(cc1S([O-])(=O)=O)S([O-])(=O)=O
Target	Reactive Oxygen Species
Solubility	H2O:70 mg/mL (183.57 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:45 mg/mL (118.01 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.24 mM)

Bioactivity

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In Vivo

NXY-059 reduces infarct volume in rats subjected to 2 hours of middle cerebral artery occlusion in a dose-dependent manner. At equimolar doses (3.0 mg/kg for NXY-059 and 1.4 mg/kg for PBN), NXY-059 is more efficacious than PBN. Similar results are obtained when a recovery period of 7 days is allowed. The window of therapeutic opportunity for NXY-059 is 3 to 6 hours after the start of recirculation. NXY-059, a free radical-trapping agent, has a substantial protective effect, lessening the disability caused by an experimentally induced stroke in a primate species. NXY-059 treatment reduces the overall amount of brain damage by >50% of saline-treatment values, with similar levels of protection afforded to both white and gray matter. Treatment with NXY-059 (50 mg/kg subcutaneous plus 8.8 mg/kg/h for 3 days subcutaneous delivered via implanted osmotic pumps) significantly decreases neurological impairment following intracerebral hemorrhage in rat, and reduces the neutrophil infiltrate observed 48 hours post-hemorrhage in the vicinity of the hematoma, and the number of TUNEL-positive cells 48 hours post-hemorrhage at the hematoma margin.

Storage & Handling

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Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Reactive Oxygen Species, ReactiveOxygenSpecies, NXY 059, NXY059, NXY-059, OKN 007, OKN007, OKN-007, inhibit, Inhibitor, Cerovive, Disufenton, Disufenton sodium

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Compound Identifiers

PubChem CID

6440181 ↗

Key Properties

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No computed properties available.

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