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DJ-V 159

SKU: orb1302091
FeaturedFeatured Product

Description

DJ-V-159

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

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DJ-V 159

Key Properties

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CAS Number2253744-53-3
MW502.4
Purity>98%
FormulaC24H12F6N4O2
SMILESFC(F)(F)c1cc(NC(=O)c2cccc(c2)C(=O)Nc2ccc(C#N)c(c2)C(F)(F)F)ccc1C#N
TargetGPCR
SolubilitySoluble in DMSO (up to 60 mg/ml)

Bioactivity

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In Vivo
DJ-V-159 (10 mg/kg, i.p.) reduces blood glucose levels in wild-type mice at 60 and 90 minutes, whereas the vehicle (95% PEG + 5% DMSO) has no effect on blood glucose. DJ-V-159 (10 mg/kg, i.p.) reduces blood glucose levels in wild-type mice by 43.6% and 41.9% at 60 and 90 minutes, respectively. The mice tolerated this short-term exposure to DJ-V-159 without any overt side-effects. DJ-V-159, however, is almost in or on the boundary of the Lipinski's Rule of Five .
In Vitro
DJ-V159 activates ERK in HEK-293 cells transfected with GPRC6A but not in non-transfected HEK-293 cells, with potency similar to L-Arg. Additionally, DJ-V159 dose-dependently stimulates cAMP production in GPRC6A-expressing HEK-293 cells at 0.2 nM concentrations in the media. DJ-V159 also stimulates insulin secretion in mouse beta-cell MIN-6 cells, with an insulin stimulation index (SI) similar to Ocn, a known ligand of GPRC6A .

Storage & Handling

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StorageRT
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Androgen Receptor, AndrogenReceptor, DJ V 159, DJ-V 159, DJV159, DJ-V159, DJ-V-159, inhibit, GPRC6A, Inhibitor
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
137319717 ↗

Key Properties

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No computed properties available.

Protocol Information

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5 mg
$ 170.00
25 mg
$ 350.00
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