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Dopamine D4 receptor ligand 3

SKU: orb3027813

Description

Dopamine D4 receptor ligand 3 (Compound 16) functions as a dopamine D4 receptor (D4R) antagonist with a pKi of 8.86. In HEK-293T cells, it shows pIC50 values of 5.78, 5.55, and 6.17 for Go, Gi, and βArr2 sensors, respectively. This compound inhibits the activity of human glioma cell lines U87 MG, T98G, and U251 MG, and it induces ROS production and mitochondrial dysfunction in these glioma cells.

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number3082344-46-2
MW489.56
FormulaC28H31N3O5
SMILESO=C(O)C(=O)O.O=C1N(C=2C=CC=CC2CC1)CCCN3CCN(C=4C=CC=5C=CC=CC5C4)CC3
TargetReactive Oxygen Species,Dopamine Receptor

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information