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Dopamine

SKU: orb1217941

Description

Dopamine is an inotropic vasopressor agent and dopamine receptor agonist used in neurological diseases.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number51-61-6
MW153.18
Purity>98% (HPLC)
FormulaC8H11NO2
SMILESC1=CC(=C(C=C1CCN)O)O
TargetDopamine Receptor
SolubilityDMSO:10 mM

Bioactivity

In Vivo
Dopamine (50 mg/kg; i.p. injection; days 1-7) strongly and selectively inhibits the vascular permeabilizing and angiogenic activities of VPF/VEGF. Animal model: Syngeneic C3Heb/FeJ mice with MOT ascites tumors. Dosage: 50 mg/kg. Administration: i.p. injection; 7 days. Result: Corresponding to ~5% of the median lethal dose (LD50) in mice) beginning at 24 hours after tumor-cell injection and continuing daily for 7 days.
In Vitro
Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) strongly stimulates human umbilical vein endothelial cells (HUVECs) proliferation. The stimulatory effect of VPF/VEGF is abrogated by Dopamine (1 μM; 24 hours). Cell Proliferation Assay Cell line: HUVECs. Concentration: 1 μM. Incubation time: 24 hours. Result: Inhibited VPF/VEGF-induced HUVEC proliferation specifically through its D2 receptor.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information