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Doravirine

SKU: orb1303977

Description

Doravirine (MK-1439) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) for HIV-1 research. It is utilized in antiviral studies to investigate mechanisms of action and resistance, with applications in both in vitro enzymatic assays and in vivo animal models of HIV infection.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1338225-97-0
MW425.75
Purity99.79% (May vary between batches)
FormulaC17H11ClF3N5O3
SMILESCn1c(Cn2ccc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)n[nH]c1=O
TargetHIV Protease,Reverse Transcriptase
Solubility10% DMSO+90% Corn Oil:2 mg/mL (4.7 mM);DMSO:45 mg/mL (105.7 mM)

Bioactivity

Target IC50
K103N/Y181C:33 nM|Y181C:31nM|K103N:21nM|Virus (WT):12nM
In Vivo
Administration of 50 mg doravirine with a high-fat meal is associated with slight elevations in AUC time zero to infinity (AUC0-∞) and C24 h with no change in Cmax. Midazolam AUC0-∞ is slightly reduced by coadministration of doravirine (geometric mean ratio 0.82, 90% CI 0.70, 0.97).
In Vitro
Doravirine exhibits potent antiviral activity against wild-type virus and K103N, Y181C, and K103N/Y181C mutant viruses, with IC50 value of 12, 21, 31, and 33 nM, respectively. MK-1439 exhibited similar antiviral activities against 10 different HIV-1 subtype viruses (a total of 93 viruses).

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Doravirine, HIV, HIV Protease, HIV-1, HIVProtease, Inhibitor, Human immunodeficiency virus, inhibit, MK 1439, MK1439, MK-1439, ReverseTranscriptase, Reverse Transcriptase

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Doravirine (orb1303977)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,170.00
2 mg
¥ 1,430.00
5 mg
¥ 1,820.00
1 ml x 10 mM (in DMSO)
¥ 2,340.00
10 mg
¥ 2,860.00
25 mg
¥ 5,200.00
50 mg
¥ 7,670.00
100 mg
¥ 10,790.00
500 mg
¥ 21,710.00
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