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DPP9-IN-2

SKU: orb3174400

Description

DPP9-IN-2 is a selective and potent orally active inhibitor of dipeptidyl peptidase 9 (DPP9), with an IC50 value of 12.9 nM. It exhibits a selectivity index of 59 for DPP8 and shows no significant inhibitory activity on related peptidases, including DPP2, DPP4, FAP, and PREP. DPP9-IN-2 can induce pyroptosis in cancer cells and demonstrates modest synergistic anti-HIV-1 activity when combined with non-nucleoside reverse transcriptase inhibitors. This compound is applicable for research in cancer and infection.

Images & Validation

Key Properties

CAS Number3020859-44-0
MW541.64
FormulaC33H33F2N3O2
SMILESO=C(NC12CC3CC(C1)CC(NCC(=O)N4CC5=CC=C(F)C=C5C4)(C3)C2)C6=CC=C(C=C6)C=7C=CC(F)=CC7
TargetPyroptosis,Proteasome,HIV Protease

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information