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Droloxifene

SKU: orb1709831

Description

Droloxifene (3-Hydroxytamoxifen) is an orally active SERM derived from tamoxifen. It induces p53 expression and apoptosis in MCF-7 breast cancer cells in vitro and has demonstrated bone-protective effects in ovariectomized rat models in vivo.

Research Area

Cell Biology, Metabolism Research

Images & Validation

Key Properties

CAS Number82413-20-5
MW387.51
Purity99.27%
FormulaC26H29NO2
SMILESCC\C(=C(\c1ccc(OCCN(C)C)cc1)c1cccc(O)c1)c1ccccc1
TargetEstrogen Receptor/ERR,Apoptosis
SolubilityDMSO:40 mg/mL (103.22 mM);10% DMSO+90% Corn Oil:4 mg/mL (10.32 mM)

Bioactivity

In Vivo
Droloxifene (5-20 mg/kg,P.o.;Daily for 4 weeks can bring THE BMD of DFM up to 10mg/kg and completely prevent OVX from reducing the BMC and BMD of DFM at 20mg /kg/day.
In Vitro
Droloxifene induces apoptosis in MCF-7 cells(10 nM; 16-18 hours).

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

estrogen receptor, Estrogen Receptor, EstrogenReceptor, ERR, 3-Hydroxytamoxifen, Droloxifene

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Key Properties

No computed properties available.

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Droloxifene (orb1709831)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

500 mg
1 mg
¥ 1,170.00
5 mg
¥ 2,080.00
1 ml x 10 mM (in DMSO)
¥ 2,340.00
10 mg
¥ 2,860.00
25 mg
¥ 4,420.00
50 mg
¥ 6,370.00
100 mg
¥ 8,320.00