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DuP-697

SKU: orb1707352

Description

DuP-697 is an irreversible and selective COX-2 inhibitor with an IC50 of 10 nM for human COX-2 versus 800 nM for COX-1. This small molecule is a valuable research tool for studying inflammation, angiogenesis, and apoptosis in both cellular and animal models of disease.

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience

Images & Validation

Key Properties

CAS Number88149-94-4
MW411.31
Purity>99.99% (May vary between batches)
FormulaC17H12BrFO2S2
SMILESCS(=O)(=O)c1ccc(cc1)-c1cc(Br)sc1-c1ccc(F)cc1
TargetCOX,Apoptosis
SolubilityDMSO:45 mg/mL (109.41 mM)

Bioactivity

Target IC50
COX-1 (human):800 nM|COX-2 (human):10 nM
In Vivo
METHODS: DuP 697 (5 mg/kg, intraperitoneal injection) was used to treat rats 1 hour before thrombin injection to investigate its neurotoxic effects on dopaminergic neuronal degeneration in the substantia nigra (SN) of rats. RESULTS The loss of TH-ip neurons was partially attenuated in the SN of rats treated with DuP-697.
In Vitro
METHODS: DuP-697 (0, 12.5, 25, 50, 100, 200 μM, 36 hours) was used to treat K562 or CML cell lines. The effects on cell growth were evaluated by MTT assay, and the effects on cell apoptosis were detected by flow cytometry. RESULTS DuP-697 significantly inhibited the growth of K562 cells and primary CML cells with an IC50 value of 31.7 μM, and induced cell apoptosis in a concentration-dependent manner.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

COX-1, COX-2, DuP697, DuP-697, DuP 697, hCOX-1, hCOX-2
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Key Properties

No computed properties available.

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DuP-697 (orb1707352)

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Available Sizes

Select a size below

1 mg
¥ 1,170.00
5 mg
¥ 1,950.00
1 ml x 10 mM (in DMSO)
¥ 2,210.00
10 mg
¥ 2,600.00
25 mg
¥ 4,030.00
50 mg
¥ 5,590.00
100 mg
¥ 8,060.00
200 mg
¥ 11,180.00
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