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Duvelisib

SKU: orb1306832

Description

Duvelisib

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number1201438-56-3
MW416.87
Purity>98%
FormulaC22H17ClN6O
SMILESC[C@H](Nc1ncnc2[nH]cnc12)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1
TargetKinase
SolubilitySoluble in DMSO (up to at least 25 mg/ml)

Bioactivity

Target IC50
p110δ:2.5 nM|PI3Kβ:1564 pM(Ki)|PI3Kγ:243 pM(Ki)|p110α:1602 nM|p110γ:27.4 nM|p110β:85 nM|PI3Kδ:23 pM(Ki)
In Vivo
METHODS: We used an Eμ-TCL1 adoptive transfer mouse model of CLL. After Duvelisib (INK1197, IPI-145) (100 mg/kg, once daily, oral, for 21 days), RESULTS Duvelisib (INK1197, IPI-145) significantly reduced the CLL burden (CD19 CD5 B cells) in the peripheral blood of mice; at the same time, the total number of CD3 T cells in the mice was also lower, but the CD4/CD8 ratio was also reduced.
In Vitro
METHODS: Primary AML blasts (AML#2 and AML#5) were treated with Duvelisib (INK1197, IPI-145) (0.1, 0.5, 1 μM) and cultured for 4 hours. They were then incubated with BMSC conditioned medium for 5 minutes. Whole cell extracts were prepared and Western blot analysis was performed for pAKT (s473 and t308) and total AKT, as well as pMAPK and total MAPK. RESULTS Duvelisib (INK1197, IPI-145) inhibited BMSC CM-induced pAKT (s473 and t308) activation at 0.1 μM; Duvelisib (INK1197, IPI-145) blocked blast migration through its inhibitory effect on AKT phosphorylation at the t308 site.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

IPI-145

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Key Properties

No computed properties available.

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Duvelisib (orb1306832)

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5 mg
¥ 2,600.00
25 mg
¥ 4,550.00
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