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E 64c

SKU: orb1300647

Description

E-64c (EP 475) is a cell-permeable, irreversible inhibitor of cysteine proteases. This compound is widely used in biochemical research to study protease function in both cellular (in vitro) and animal (in vivo) models of diseases such as muscular dystrophy and cancer.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number76684-89-4
MW314.38
Purity99.90% (May vary between batches)
FormulaC15H26N2O5
SMILESCC(C)CCNC(=O)C(CC(C)C)NC(=O)C1OC1C(O)=O
TargetCysteine Protease|||SARS-CoV
SolubilityH2O:2 mg/mL (6.36 mM);DMSO:58 mg/mL (184.49 mM);Ethanol:58 mg/mL (184.49 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.36 mM)

Bioactivity

In Vivo
In pectoral muscle of dystrophic chickens, Loxistatin Acid (E-64C) normalizes the increased activities of cathepsin B and cathepsin H. E-64C inhibits ischemic degradation of cerebral proteins following occlusion of the middle cerebral artery in rats.
In Vitro
Loxistatin Acid (E-64C), as a thiol protease inhibitor, inhibits calpain activity in intact platelets. E-64C inhibits β-secretase activity in regulated secretory vesicles of neuronal chromaffin cells, and decrease Aβ production, indicating a therapeutic strategy for Alzheimer's disease.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

NSC694279, NSC-694279, Loxistatin Acid, NSC 694279, inhibit, Inhibitor, EP475, EP-475, EP 475, Cathepsin, E 64c, CysteineProtease, Cysteine Protease, Cysteine protease, SARS coronavirus, SARSCoV, SARS-CoV

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 90.00
5 mg
$ 150.00
1 ml x 10 mM (in DMSO)
$ 160.00
10 mg
$ 220.00
25 mg
$ 340.00
50 mg
$ 500.00
100 mg
$ 700.00
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