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E6-272

SKU: orb2664143

Description

E6-272 is a small molecule inhibitor of HPV16, inducing apoptosis and inhibiting proliferation in HPV16-positive cervical cancer cell lines such as SiHa and CaSki. Its research applications include investigating HPV oncoprotein function and exploring potential antiviral and anticancer strategies in vitro.

Research Area

Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number945142-65-4
MW384.51
Purity99.82%
FormulaC26H28N2O
SMILESO=C(Cc1ccc(cc1)-c1ccccc1)NC1CCN(Cc2ccccc2)CC1
TargetVirus Protease
SolubilityDMSO:8 mg/mL (20.81 mM)

Bioactivity

In Vitro
Methods: SIHA and CASKI cells were treated with E6-272 (15nM; 30nM, 48 hours) and apoptosis analysis was performed to evaluate the efficacy of E6-272 in inducing apoptosis in cervical cancer cells. Results: E6-272 (15nM) treatment of SIHA cells induced 27.85% early and 8.38% late apoptotic cell populations (Figure 8). E6-272 (30nM) treatment of CASKI cells showed 23.94% and 7.42% early and late apoptotic cell populations, respectively.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

E6272, E 6-272
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Key Properties

No computed properties available.

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Protocol Information

E6-272 (orb2664143)

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Available Sizes

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1 mg
¥ 1,170.00
1 ml x 10 mM (in DMSO)
¥ 1,820.00
5 mg
¥ 1,820.00
10 mg
¥ 2,470.00
25 mg
¥ 4,420.00
50 mg
¥ 6,370.00
100 mg
¥ 9,360.00
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