EC359

SKU: orb1709803

Description

EC359 is a potent and selective small molecule inhibitor that disrupts the LIF/LIFR interaction. It exhibits anticancer activity and is a valuable research tool for studying leukemia and endometrial cancer in both in vitro and in vivo models.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	2012591-09-0
MW	540.68
Purity	98.11%
Formula	C₃₆H₃₈F₂O₂
SMILES	[H][C@@]12CC[C@@](O)(C(F)(F)C#C)[C@@]1(C)C[C@@H](C1=C3CCC(=O)C=C3CC[C@@]21[H])c1ccc(cc1)-c1c(C)cc(C)cc1C
Target	Apoptosis
Solubility	DMSO:100 mg/mL (184.95 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.4 mM)

Bioactivity

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Target IC50	LIFR:10.2 nM (Kd)
In Vivo	Subcutaneous injection of EC359 at a dose of 5 mg/kg, administered three days per week for 25 days in female athymic nude mice, significantly reduces tumor progression. Importantly, the body weights of mice in the EC359-treated groups remain unchanged, confirming the low toxicity of EC359. Read more...
In Vitro	EC359 treatment (0-100 nM) for 3 days in BT-549, SUM-159, MDA-MB-231, MDA-MB-468, and HCC1806 cells leads to a dose-dependent reduction in cell viability. In MDA-MB-231 and BT-549 cells, treatment with EC359 at concentrations of 20 nM and 25 nM for 72 hours significantly increases caspase-3/7 activity and the proportion of Annexin V-positive cells. EC359 exhibits noteworthy inhibitory activity on invasion and promotes apoptosis in triple-negative breast cancer (TNBC) cells.Treatment with EC359 at 100 nM for 12 hours in BT549 cells significantly decreases the expression of several known STAT3 target genes, including STAT1, TGFB1, JUNB, MCL-1, etc.In MDA-MB-231 and BT-549 cells, EC359 treatment at 100 nM for 1 hour substantially reduces STAT3 activation induced by LIF, OSM, and CNTF. Additionally, EC359 treatment leads to a significant decrease in the phosphorylation of AKT, mTOR, S6, and ERK1/2. Furthermore, EC359 treatment enhances the phosphorylation of proapoptotic p38MAPK in BT549 cells. Read more...

Storage & Handling

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Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Apoptosis, leukemia inhibitory factor receptor, EC359, EC-359, EC 359

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Compound Identifiers

PubChem CID

139600278 ↗

Key Properties

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No computed properties available.

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EC359 (orb1709803)

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EC359

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

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Protocol Information

EC359 (orb1709803)

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