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EF24

SKU: orb1305109

Description

EF24 (3,5-Bis[(2-fluorophenyl)methylene]-4-piperidinone) is a potent small molecule that induces apoptosis in oral squamous cell carcinoma (OSCC) by activating caspases 3/9 and inhibiting the MEK/ERK pathway. Its anti-tumor efficacy, demonstrated in both in vitro and in vivo studies, makes it a valuable research tool for investigating MAPK/ERK signaling in cancer.

Research Area

Cell Biology, Immunology & Inflammation, Protein Biochemistry, Signal Transduction

Images & Validation

Key Properties

CAS Number342808-40-6
MW311.33
Purity99.71%
FormulaC19H15F2NO
SMILESFc1ccccc1\C=C1/CNC\C(=C/c2ccccc2F)C1=O
TargetApoptosis,Caspase,ROS,MEK,ERK,p38 MAPK,NF-κB
SolubilityDMSO:25 mg/mL (80.3 mM)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ERK, Extracellular signal regulated kinases, EF24, EF-24, EF 24, Inhibitor, MEK1, inhibit, Caspase-3, Caspase-9, Caspase, 3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone

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Key Properties

No computed properties available.

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Protocol Information

EF24 (orb1305109)

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% DMSO +
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% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,040.00
5 mg
¥ 1,560.00
1 ml x 10 mM (in DMSO)
¥ 1,690.00
10 mg
¥ 2,340.00
25 mg
¥ 3,770.00
50 mg
¥ 5,460.00
100 mg
¥ 7,930.00
500 mg
¥ 15,990.00
1 g
¥ 21,190.00
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