Eflornithine

SKU: orb1690331

Description

Eflornithine (DFMO) is an orally active, selective inhibitor of ornithine decarboxylase used in research on African trypanosomiasis (sleeping sickness) and certain cancers like glioma. Its mechanism of inhibiting polyamine synthesis has been validated in both in vitro and in vivo experimental models for these diseases.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	70052-12-9
MW	182.17
Purity	99.44% (May vary between batches)
Formula	C₆H₁₂F₂N₂O₂
SMILES	O=C(O)C(N)(CCCN)C(F)F
Target	Parasite
Solubility	H2O:50 mg/mL (274.47 mM)

Bioactivity

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In Vivo

Eflornithine is the only newly registered molecule for the treatment of human African trypanosomiasis in the past 50 years, mainly serving as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases. In subjects with excessive facial hair, eflornithine 15% cream reduces hair growth more effectively than placebo, with 58% of eflornithine users showing improvement after 24 weeks compared to 34% for placebo. The hair growth inhibitory effect is significantly enhanced when eflornithine cream is applied to mouse skin pretreated with microneedles. In coarctation hypertensive rats, eflornithine treatment normalizes contractile responses to KCI and norepinephrine and acetylcholine-induced relaxations after 14 days.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Parasite, MDL71782, DFMO, α-difluoromethylornithine, RMI71782

Quality Guarantee

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Compound Identifiers

PubChem CID

3009 ↗

Key Properties

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No computed properties available.

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Eflornithine (orb1690331)

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Purity:	>98%
CAS Number:	70052-12-9
MW:	218.63
Formula:	C₆H₁₂F₂N₂O₂•HCl

Purity:	>98%
CAS Number:	96020-91-6
MW:	236.7
Formula:	C₆H₁₂F₂N₂O₂ • HCl • H₂O

CAS Number:	68278-23-9
MW:	218.63
Formula:	C₆H₁₃ClF₂N₂O₂

CAS Number:	66640-93-5
MW:	182.17
Formula:	C₆H₁₂F₂N₂O₂

Purity:	>98% (HPLC)
CAS Number:	96020-91-6
MW:	236.64
Formula:	C₆H₁₅ClF₂N₂O₃

Eflornithine

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

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Eflornithine hydrochloride Monohydrate [orb1223515]

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Key Properties

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Eflornithine (orb1690331)

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