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EHP-101

SKU: orb1308960

Description

EHP-101 (VCE-004.8) is a dual PPARγ/CB2 receptor agonist with significant anti-inflammatory properties. It has been shown in research to inhibit adipogenesis and counteract diet-induced obesity in vivo, positioning it as a candidate for investigating metabolic and inflammatory disorders.

Research Area

Epigenetics & Chromatin, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1818428-24-8
MW433.58
Purity99.22% (May vary between batches)
FormulaC28H35NO3
SMILESCCCCCC1=C(NCc2ccccc2)C(=O)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O
TargetPPAR,Cannabinoid Receptor,HIF/HIF Prolyl-Hydroxylase
SolubilityDMSO:49 mg/mL (113.01 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (4.61 mM)

Bioactivity

In Vivo
In HFD mice, VCE-004.8 (injection; 20 mg/kg/day; for 3 weeks) induces a significant reduction in body weight gain, total fat mass, adipocyte volume, and plasma triglycerides levels. VCE-004.8 can also significantly improve glucose tolerance, reduce leptin levels (a sign of obesity) and increase the levels of adiponectin and glucagon (GLP-1 and GIP) .

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CB, CB2, Cannabinoid Receptor, CannabinoidReceptor, inhibit, Hypoxia-inducible factors, EHP 101, EHP101, EHP-101, Inhibitor, HIF, HIF/HIF ProlylHydroxylase, HIF Prolyl-Hydroxylase, HIF ProlylHydroxylase, HIFs, HIFProlylHydroxylase, HIF-PH, HIF/HIF Prolyl-Hydroxylase, HIF/HIFProlylHydroxylase, PPARγ, PPAR, Peroxisome proliferator-activated receptors, VCE-​004.8, VCE-?004.8, VCE-004.8
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

EHP-101 (orb1308960)

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% DMSO +
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% Tween 80 +
%

Available Sizes

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1 mg
¥ 1,950.00
5 mg
¥ 3,120.00
1 ml x 10 mM (in DMSO)
¥ 3,510.00
10 mg
¥ 4,810.00
25 mg
¥ 7,540.00
50 mg
¥ 10,400.00
100 mg
¥ 13,390.00
DispatchUsually dispatched within 3-5 working days
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