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eIF4A3-IN-18

SKU: orb1744553

Description

eIF4A3-IN-18 is a potent silvestrol analog that inhibits protein synthesis by disrupting eIF4F complex formation, with EC₅₀ values in the low nanomolar range against various cellular targets. It exhibits significant cytotoxicity, particularly against cancer cell lines such as MBA-MB-231 and RMPI-8226, making it a valuable chemical probe for studying translation initiation in cancer pathogenesis research.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number1402931-84-3
MW500.54
FormulaC29H28N2O6
SMILESO[C@]12[C@]([C@@H]([C@@H](C(N(C)C)=O)[C@H]1O)C3=CC=CC=C3)(OC=4C2=C(OC)C=C(C#N)C4)C5=CC=C(OC)C=C5
TargetPERK,Others

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

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Protocol Information

eIF4A3-IN-18 (orb1744553)

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