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ELN-441958

SKU: orb1306514

Description

ELN-441958 is a highly selective and potent neutral antagonist of the B1 receptor, exhibiting a Ki of 0.26 nM against the agonist [3H]DAKD in IMR-90 cell binding assays. This compound is a valuable research tool for investigating the distinct physiological and pathological roles of the B1 receptor in inflammation, pain, and sepsis using both in vitro and in vivo models.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number913064-47-8
MW501.02
Purity98.90% (May vary between batches)
FormulaC29H29ClN4O2
SMILESClc1cccc2CN(C(=O)c12)c1cccc(c1)C(=O)N1CCC2(CC1)CCN(CC2)c1ccncc1
TargetBradykinin Receptor
SolubilityDMSO:5.02 mg/mL (10.02 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2 mM)

Bioactivity

Target IC50
Bradykinin B1:0.26 nM(ki)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

B1 Receptor, anti-hyperalgesic, BradykininReceptor, Bradykinin Receptor, low CNS exposure, inhibit, Inhibitor, high oral bioavailability, ELN441958, ELN-441958, ELN 441958

Similar Products

  • ELN 441958 [orb1223667]

    >98% (HPLC)

    913064-47-8

    501.02

    C29H29ClN4O2

    2 mg, 5 mg, 25 mg, 50 mg, 10 mg, 100 mg, 500 mg, 1 g
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 100.00
5 mg
$ 180.00
1 ml x 10 mM (in DMSO)
$ 200.00
10 mg
$ 270.00
25 mg
$ 420.00
50 mg
$ 580.00
100 mg
$ 780.00
200 mg
$ 1,030.00
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