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Eltanexor

SKU: orb1309507

Description

Eltanexor (ONO-7706) is an orally bioavailable, potent inhibitor of exportin-1 (XPO1) with an EC50 of 60.9 nM. It induces caspase-dependent apoptosis in leukemic cell lines and has demonstrated anti-leukemic activity in preclinical in vitro and in vivo research models.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1642300-52-4
MW428.29
Purity99.86% (May vary between batches)
FormulaC17H10F6N6O
SMILESNC(=O)C(=C\n1cnc(n1)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F)\c1cncnc1
TargetCRM1,Others
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.71 mM);DMSO:80 mg/mL (186.79 mM);H2O:< 0.1 mg/mL (insoluble)

Bioactivity

Target IC50
XPO1:60.9 nM(EC50)
In Vivo
KPT-8602 (15 mg/kg; oral gavage; daily for 12 days) demonstrates potent anti-lymphoblastic leukemia activity.
In Vitro
Eltanexor (KPT-8602) (1 nM; 16 hours) causes apoptosis in leukemia cell lines. KPT-8602 (2-6 nM; 72 hours) decreases cell viability in leukemia cell lines (EC50s ranging from 25 to 145 nM).

Storage & Handling

Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ATG 016, ATG016, ATG-016, Eltanexor, KPT8602, KPT-8602, KPT 8602, ONO7706, ONO-7706, ONO 7706, XPO1

Similar Products

  • Eltanexor Z-isomer [orb1709330]

    1642300-78-4

    428.29

    C17H10F6N6O

    50 mg, 100 mg, 2 mg, 25 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

Eltanexor (orb1309507)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,300.00
1 ml x 10 mM (in DMSO)
¥ 3,510.00
5 mg
¥ 3,640.00
10 mg
¥ 4,290.00
25 mg
¥ 6,630.00
50 mg
¥ 9,230.00
100 mg
¥ 13,000.00
200 mg
¥ 17,290.00
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