Emactuzumab Antibody

SKU: orb1980667

Description

Emactuzumab (RG 7155) is a high-affinity anti-CSF1R monoclonal antibody that inhibits receptor dimerization to deplete tumor-associated macrophages. It demonstrates antitumor activity in research models of cancers like diffuse tenosynovial giant cell tumor (dt-GCT), with utility in both in vitro and in vivo experimental studies.

Research Area

Signal Transduction

Images & Validation

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Key Properties

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CAS Number	1448221-67-7
MW	144.4 kDa
Purity	97.3% (SEC-HPLC)
Target	TAM Receptor,c-Fms

Bioactivity

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In Vivo	Emactuzumab (0.1、1、10、30 and 100 mg/kg; i.v.; once; male cynomolgus monkey) increased CSF-1 concentration in serum. RG7155 (0, 30, and 100 mg/kg; i.v.; once weekly; for 2 weeks; male and female cynomolgus) Efficiently reduced CSF-1R and CD68+163+ macrophages in the liver (Kupffer cells) and colon of cynomologus monkeys. Read more...
In Vitro	RG7155 (30 μg/mL; 6 days) induces cell death of in vitro-differentiated human M2-like macrophages. Inducing cell death, RG7155 (0-10 μg/mL; 7 days) inhibited the viability of CSF-1-differentiated macrophages with an IC50 of 0.3 nM. Emactuzumab, with a high affinity binding to human and cynomolgus CSF-1R (Kd = 0.2 nM), effectively prevents CSF-1R dimerization. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Emactuzumab, cFms, CSF1R, RO5509554, RO-5509554, RO 5509554, RG 7155, RG7155, RG-7155, TAMReceptor, TAM Receptor, TAM

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Gene Symbol

TAM Receptor,c-Fms

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