Pruvanserin hydrochloride

SKU: orb1704549

Description

Pruvanserin hydrochloride is a potent and selective inverse agonist of the 5-HT2A receptor, demonstrating high affinity in vitro with IC₅₀ values of 0.35 nM (human) and 1 nM (rat). Its functional activity, shown by inhibiting GTPγS accumulation, supports research in neuropsychiatric disorders such as schizophrenia, Parkinson's disease, and insomnia, with in vivo evidence of efficacy in rodent models of diabetic neuropathic pain.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	443144-27-2
MW	412.89
Purity	99.60%
Formula	C₂₂H₂₂ClFN₄O
SMILES	Cl.N#CC1=CNC2=C1C=CC=C2C(=O)N3CCN(CCC4=CC=C(F)C=C4)CC3
Target	5-HT Receptor
Solubility	Ethanol:< 8 mg/mL;DMSO:< 32 mg/mL

Bioactivity

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Target IC50	5-HT2A Receptor (rat):1 nM\|5-HT2A Receptor (human):0.35 nM

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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LY 2422347 hydrochloride, LY2422347 hydrochloride, EMD281014 hydrochloride, EMD281014 Hydrochloride, EMD-281014 Hydrochloride, EMD 281014 Hydrochloride, EMD 281014 hydrochloride

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Compound Identifiers

PubChem CID

9887933 ↗

Key Properties

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No computed properties available.

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