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Pruvanserin hydrochloride

SKU: orb1704549

Description

Pruvanserin hydrochloride is a potent and selective inverse agonist of the 5-HT2A receptor, demonstrating high affinity in vitro with IC₅₀ values of 0.35 nM (human) and 1 nM (rat). Its functional activity, shown by inhibiting GTPγS accumulation, supports research in neuropsychiatric disorders such as schizophrenia, Parkinson's disease, and insomnia, with in vivo evidence of efficacy in rodent models of diabetic neuropathic pain.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number443144-27-2
MW412.89
Purity99.60% (May vary between batches)
FormulaC22H22ClFN4O
SMILESCl.N#CC1=CNC2=C1C=CC=C2C(=O)N3CCN(CCC4=CC=C(F)C=C4)CC3
Target5-HT Receptor
SolubilityEthanol:< 8 mg/mL;DMSO:< 32 mg/mL

Bioactivity

Target IC50
5-HT2A Receptor (rat):1 nM|5-HT2A Receptor (human):0.35 nM

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

LY 2422347 hydrochloride, LY2422347 hydrochloride, EMD281014 hydrochloride, EMD281014 Hydrochloride, EMD-281014 Hydrochloride, EMD 281014 Hydrochloride, EMD 281014 hydrochloride
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 mg
$ 270.00
5 mg
$ 620.00
10 mg
$ 870.00
25 mg
$ 1,900.00
50 mg
$ 3,430.00
DispatchUsually dispatched within 6-8 weeks
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