Enavatuzumab Antibody

SKU: orb1980579

Description

Enavatuzumab (PDL192) is a humanized anti-TWEAKR monoclonal antibody with anti-tumor activity. It functions by recruiting and activating myeloid effector cells to mediate tumor cell killing, and it has been investigated in preclinical in vivo and in vitro studies for late-stage solid tumors.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	1062149-33-0
MW	150 kDa
Purity	98.7% (SEC-HPLC)
Target	TNF

Bioactivity

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In Vivo	Enavatuzumab achieved 70% tumor growth inhibition (TGI) in vivo against H358 tumors.
In Vitro	Enavatuzumab has growth inhibiting activity in a wide range of cancer cell lines in vitro. Enavatuzumab (10 μg/mL) and cells incubated together for 24 hours resulted in significantly increased migration of immune effector cells to SN12C and A375 tumor cells. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Anti-TNFRSF12A/TWEAKR/CD266 Reference Antibody, ABT361, ABT-361, PDL192, PDL-192

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Gene Symbol

TNF

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