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ERβ agonist-1

SKU: orb3027724

Description

ERβagonist-1 (Compound 8) functions as a dual-active selective ERβ agonist (EC50: 46.8 nM) and an AR antagonist (IC50: 1555 nM). By binding to ERβ, it activates its signaling pathways while simultaneously inhibiting AR activity. Retaining selective ERβ agonist activity in mouse models, ERβagonist-1 is applicable in prostate cancer research.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2412715-30-9
MW368.55
FormulaC25H36O2
SMILESC(CCC(C)C)[C@@]12C(=C3[C@](C)(CC1)C=4C(CC3)=C(C)C(O)=CC4)C[C@@H](O)C2
TargetAndrogen Receptor,Estrogen Receptor/ERR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information