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ERBB agonist-1

SKU: orb2945687

Description

ERBB agonist-1 (EF-1) is a small molecule ERBB4 agonist (EC50: 10.5 µM) that induces receptor dimerization, activating Akt/ERK signaling. It demonstrates cardioprotective effects in vitro by inhibiting cardiomyocyte death and fibrosis, and in vivo by attenuating cardiac hypertrophy and fibrosis in mouse models.

Research Area

Cardiovascular Research, Signal Transduction

Images & Validation

Key Properties

CAS Number930856-19-2
MW419.54
Purity99.90%
FormulaC24H25N3O2S
SMILESO=C1C=2C=CC=CC2N=C(SC(C(=O)NC3CC3)C=4C=CC=CC4)N1C5CCCC5
TargetEGFR,ERK,Akt

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

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ERBB agonist-1 (orb2945687)

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1 mg
¥ 1,040.00
5 mg
¥ 1,560.00
1 ml x 10 mM (in DMSO)
¥ 1,690.00
10 mg
¥ 2,210.00
25 mg
¥ 3,770.00
50 mg
¥ 5,330.00
100 mg
¥ 7,670.00
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