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Esculentoside A

SKU: orb1221912

Description

Esculentoside A can suppress inflammatory responses in LPS-induced ALI through inhibition of the NF-κB and mitogen-activated protein kinase signaling pathways. Esculentoside A may be useful for the treatment of autoimmune disease through modulation on T cell-mediated adaptive immunity. Esculentoside A may play significant roles in the treatment of BXSB mice through modulation of inflammatory cytokines, inhibition of renal cell proliferation and induction of apoptosis.

Images & Validation

Key Properties

CAS Number65497-07-6
MW826.96
Purity>98% (HPLC)
FormulaC42H66O16
SMILES[C@@H]1([C@H](C[C@]2([C@H]([C@@]1(CO)C)CC[C@@]1(C)[C@]3(C)CC[C@@]4(C(=O)O)CC[C@](C)(C(=O)OC)C[C@H]4C3=CC[C@H]21)C)O)O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@H](O2)CO)CO1
TargetNF-κB
SolubilityIn Vitro: DMSO : 100 mg/mL (120.92 mM)

Bioactivity

In Vivo
Animal model: BXSB mice. Dosage: 20 mg/kg. Administration: Intraperitoneal injection; 20 mg/kg; once a day; 4 weeks. Result: Alleviated the renal damage of LN.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Esculentoside A (orb1221912)

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200 mg
500 mg
5 mg
¥ 1,430.00
10 mg
¥ 2,340.00
25 mg
¥ 3,900.00
50 mg
¥ 5,720.00
100 mg
¥ 8,320.00