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Estrogen receptor modulator 10

SKU: orb1942327

Description

Compound G-5b is a potent estrogen receptor antagonist (IC50=6.7 nM) and degrader (DC50=0.4 nM) that induces apoptosis and G1/G0 cell cycle arrest. Its mechanism supports research into ER-positive cancers, such as breast cancer, in both cellular and animal model studies.

Research Area

Cell Biology, Metabolism Research, Protein Biochemistry

Images & Validation

Key Properties

CAS Number2991504-90-4
MW728.71
FormulaC32H37F9N4O3S
SMILESC(C(CO)(F)F)N1[C@@H](C2=C(C=3C(N2)=CC=CC3)C[C@H]1C)C4=C(F)C=C(NC5CN(CCCS(CCCC(C(F)(F)F)(F)F)(=O)=O)C5)C=C4F
TargetCaspase,Estrogen Receptor/ERR,Bcl-2 Family

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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Protocol Information

Estrogen receptor modulator 10 (orb1942327)

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